Suggest people to prevent engaging in harmful tasks necessitating mental alertness and motor coordination immediately after ingestion of promethazine HCl and codeine phosphate oral Option. Keep away from concurrent usage of promethazine HCl and codeine phosphate oral Resolution with alcohol or other central anxious procedure depressants due to the fact added impairment of central nervous procedure performance may perhaps arise [see Warnings and Precautions (five.ten)].
Like all opioids, codeine could potentially cause physical dependence. To stop symptoms of withdrawal, individuals that use codeine for some time may possibly come to feel the necessity to utilize it daily.
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Accidental Ingestion: Accidental ingestion of even one dose, Specifically by little ones, can result in a lethal overdose of codeine.
If you need to consider it for years Your entire body may become used to it (called tolerance). That means you need higher doses to manage your soreness after a while.
g., amiodarone, quinidine) might cause a rise in codeine plasma concentrations plus a minimize in Energetic metabolite morphine plasma concentration which could bring about an analgesic efficacy reduction or symptoms of opioid withdrawal.
If this advice doesn't assist and any of these Uncomfortable side effects continue on to trouble you, talk to your medical doctor or pharmacist.
The causal part of opioids from the medical syndrome of hypogonadism is mysterious because the a variety of clinical, Actual physical, Way of living, and psychological stressors that may impact gonadal hormone more info concentrations haven't been adequately managed for in reports performed to this point [see Adverse Reactions (six)].
Experience dizzy and vertigo If codeine would make you really feel dizzy when you stand up, try acquiring up really bit by bit or keep sitting down till you feel superior. If you begin to really feel dizzy, lie down so you tend not to faint, then sit until eventually you really feel greater.
Avoid the use of promethazine HCl and codeine phosphate oral Answer in individuals who're taking a CYP3A4 inhibitor, CYP3A4 inducer, or 2D6 inhibitor [see Warnings and
Get this medication specifically as prescribed to reduced the risk of dependancy. Question your medical professional or pharmacist for more details.
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Promethazine and codeine mixture is employed to relieve cough, runny or stuffy nose, sneezing, or other indications a result of allergic reactions or the popular cold.
Acute or serious bronchial bronchial asthma in an unmonitored placing or in absence of resuscitative machines. (4)